Although the prospective use of the CFIR has been infrequent , the CFIR can be used to design an implementation strategy. After completing a context assessment and identifying barriers and facilitators to implementing an innovation, the CFIR can help tailor implementation strategies to mitigate barriers and leverage facilitators. This process can also be used to refine implementation processes through the course of implementation.
An overarching theory in Implementation Science states that implementation will be successful when implementation strategies are highly tailored and responsive to local context . However, evidence supporting this theory is mixed [3,4], and authors have concluded that additional research is needed on how to appropriately tailor strategies in order to be able to accurately assess their effects [2,3].
Current research suggests that implementation strategies must be tailored over time to address multiple contextual levels :
- Individual level behavior change [5,6]
- Collective (team, organization, etc.) level change [7-9]
- Structural/policy/legal level change
Using innovative trial designs and methods from other disciplines will help build the knowledge needed about how to tailor strategies:
- “Agile science” methods 
- Flexible adaptive intervention design [15-16]
- Dynamic randomization of micro intervention components 
The Expert Recommendations for Implementing Change (ERIC) provides a compilation of 73 implementation strategies [7-8]; these strategies were mapped to CFIR constructs . Based on this work, The CFIR-ERIC Matching Tool v1.0 was developed to guide users in choosing ERIC strategies based on the results of a context assessment using the CFIR. The article describing this Tool is published and is highlighted on this website. Strategies are marked as a Level 1 or Level 2 recommendation:
- Level 1: These are strategies with the strongest consensus about their likely ability to address the respective CFIR barrier. Specifically, more than 50% of respondents chose the strategy as being one of seven best strategies to address the CFIR construct.
- Level 2: These are strategies with the second strongest consensus about their likely ability to address the respective CFIR barrier. Specifically, between 20% and 49% of respondents chose the strategy as being one of seven best strategies to address the CFIR construct
An implementation evaluation of the Telephone Lifestyle Coaching program (TLC) was conducted within 11 Veterans Affairs (VA) medical centers . This study identified seven determinants of implementation outcomes  based on a CFIR construct assessment.
The CFIR-ERIC Matching Tool can be used to select the seven CFIR constructs and generate a list of suggested strategies. An output table (abbreviated to include only strategies with Tier 1 or 2 endorsement for at least one construct) lists the seven CFIR constructs across the top in columns. ERIC implementation strategies are listed in rows, sorted by level of endorsement. “Cumulative Percent” indicates the relative strength of endorsement for the combination of constructs. For example, “Identify and Prepare Champions” has the highest cumulative endorsement (248%) for addressing the seven constructs. This strategy has Tier 1 endorsement, where a majority of respondents chose this as being one of seven strategies best able to address two constructs (Engaging: Formally Appointed Internal Implementation Leader & Engaging: Key Stakeholders); it also has Tier 2 endorsements for four additional constructs. In effect, “Identify and Prepare Champions” is a high priority strategy to consider.
Several limitations apply. The most important caveat is the relative lack of consensus on which strategies best address each CFIR construct; lack of consensus is likely driven by differences in assumptions about the precise mechanism of each strategy. Assumptions likely varied among respondents due to the diversity in training, discipline, and setting. Strategies must be more specifically described  so they can be replicated and researchers can learn what works where and why.
- Kirk MA, Kelley C, Yankey N, Birken SA, Abadie B, Damschroder L. A systematic review of the use of the consolidated framework for implementation research. Implementation Science. 2015 Dec;11(1):72.
- Chambers DA, Glasgow RE, Stange KC. The dynamic sustainability framework: addressing the paradox of sustainment amid ongoing change. Implementation Science. 2013 Dec;8(1):117.
- See: https://implementationscience.biomedcentral.com/articles/10.1186/s13012-016-0536-x)
- Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, Robertson N, Wensing M, Fiander M, Eccles MP, Godycki-Cwirko M, van Lieshout J, Jäger C. Tailored interventions to address determinants of practice. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No.: CD005470. DOI: 10.1002/14651858.CD005470.pub3.
- Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implementation science. 2012 Dec;7(1):37.
- See: http://www.behaviourchangewheel.com
- Powell BJ, Waltz TJ, Chinman MJ, Damschroder LJ, Smith JL, Matthieu MM, Proctor EK, Kirchner JE. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implementation Science. 2015 Dec;10(1):21.
- Waltz TJ, Powell BJ, Matthieu MM, Damschroder LJ, Chinman MJ, Smith JL, Proctor EK, Kirchner JE. Use of concept mapping to characterize relationships among implementation strategies and assess their feasibility and importance: results from the Expert Recommendations for Implementing Change (ERIC) study. Implementation Science. 2015 Aug 7;10(1):1.
- Waltz TJ, Powell BJ, Chinman MJ, Smith JL, Matthieu MM, Proctor EK, Damschroder LJ, Kirchner JE. Expert recommendations for implementing change (ERIC): protocol for a mixed methods study. Implementation Science. 2014 Dec;9(1):39.
- Powell BJ, Beidas RS, Lewis CC, Aarons GA, McMillen JC, Proctor EK, Mandell DS. Methods to improve the selection and tailoring of implementation strategies. The journal of behavioral health services & research. 2017 Apr 1;44(2):177-94.
- Colquhoun HL, Squires JE, Kolehmainen N, Fraser C, Grimshaw JM. Methods for designing interventions to change healthcare professionals’ behaviour: a systematic review. Implementation Science. 2017 Dec;12(1):30.
- See: https://interventionmapping.com/
- Lewis CC, Klasnja P, Powell B, Tuzzio L, Jones S, Walsh-Bailey C, Weiner B. From classification to causality: Advancing Understanding of Mechanisms of change in implementation science. Frontiers in public health. 2018;6:136.
- Hekler EB, Klasnja P, Riley WT, Buman MP, Huberty J, Rivera DE, Martin CA. Agile science: creating useful products for behavior change in the real world. Transl Behav Med. 2016 Jun; 6 (2): 317–28. doi: 10.1007/s13142-016-0395-7.
- Nahum-Shani I, Qian M, Almirall D, Pelham WE, Gnagy B, Fabiano GA, Waxmonsky JG, Y u J, Murphy SA. Experimental design and primary data analysis methods for comparing adaptive interventions. Psychological methods. 2012 Dec;17(4):457.
- Nahum-Shani I, Smith SN, Spring BJ, Collins LM, Witkiewitz K, Tewari A, Murphy SA. Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support. Annals of Behavioral Medicine. 2017 Dec 12;52(6):446-62.
- Klasnja P, Hekler EB, Shiffman S, Boruvka A, Almirall D, Tewari A, Murphy SA. Microrandomized trials: An experimental design for developing just-in-time adaptive interventions. Health Psychology. 2015 Dec;34(S):1220.
- See: https://www.hsrd.research.va.gov/for_researchers/cyber_seminars/archives/video_archive.cfm?SessionID=1060. Slide 49.
- Damschroder LJ, Reardon CM, Sperber N, Robinson CH, Fickel JJ, Oddone EZ. Implementation evaluation of the telephone lifestyle coaching (TLC) program: organizational factors associated with successful implementation. Translational behavioral medicine. 2016 Sep 29;7(2):233-41.
- Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, Griffey R, Hensley M. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health and Mental Health Services Research. 2011 Mar 1;38(2):65-76.
- Proctor EK, Powell BJ, McMillen JC. Implementation strategies: recommendations for specifying and reporting. Implementation Science. 2013 Dec;8(1):139.